Yes, it is possible to take too many antioxidants, especially taking too much of a single type of antioxidant such as vitamin E or C. An excessive amount of a single antioxidants can actually cause pro-oxidation or cause creation of an excess of free radicals. As in everything, moderation is a good guide. There is less chance of pro-oxidation with OProCyn because the ingredients contain many different forms of antioxidants which have different properties and functions as opposed to a heavy dose of a single type of antioxidant. And with the barrage of chemicals, toxins, unhealthy foods and stress in our modern lives, almost everyone is challenged by an unhealthy excess of free radicals. To gain maximum benefit, simply follow the directions on the product label or take as guided by your health professional.